Experimental evidence suggests that more sodium salts are not necessarily bad for diabetics. For example, a recent paper describing a prospective cohort study looking at the correlation between sodium and outcomes in Type 2 diabetic patients concluded that:
“lower 24-h urinary sodium excretion was paradoxically associated with increased all-cause and cardiovascular mortality.” (1)
Therefore, too little sodium can increase the risk of long term complications like cardiovascular disease.
In a nationwide multicenter study (the FinnDiane Study) between 1998 and 2002, 2,807 enrolled adults with type 1 diabetes were prospectively followed to look at the correlation between sodium excretion and health outcomes, yielding the following results. The study concluded that, “urinary sodium excretion was nonlinearly associated with all-cause mortality, such that individuals with the highest day sodium excretion was inversely associated with the cumulative incidence of ESRD, such that individuals with the lowest sodium excretion had the highest cumulative incidence of ESRD.” ESRD urinary sodium excretion, as well as the lowest excretion, had reduced survival. This association was independent age, sex, duration of diabetes, the presence and severity of chronic kidney disease (CKD) (estimated glomerular filtration rate [eGFR] and log albumin excretion rate), the presence of established cardiovascular disease, and systolic blood pressure. During follow-up, 126 patients developed ESRD (4.5%).” (2)
Therefore, the high amount of elemental sodium contained in Auxulin’s formulation has a small risk, which we believe is a justifiable risk to reduce the more immediate risk of ketoacidosis for a hyperglycemic person. Moreover, we believe that the long term risks associated with higher A1C levels (for individuals not taking Auxulin) are likely to be much greater than any long-term increase in risk of heart disease that a diabetic might encounter as a result of a lifetime of using Auxulin. In other words, we believe Auxulin will reduce both short term and long-term health risks. Any concerns about an individual’s health should be brought up to their health care provider(s).
